Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

نویسندگان

  • Greg L Beilhartz
  • John Tam
  • Zhifen Zhang
  • Roman A Melnyk
چکیده

New insights into the mechanism of action of ebselen, a small-molecule antivirulence agent that reduces disease pathology in a mouse model of Clostridium difficile infection, suggest a different molecular target may be responsible for its efficacy.

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Response to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".

Ebselen's antivirulence activity in Clostridium difficile infection is likely due to multiple modes of action, but the contribution of each to its efficacy remains unclear.

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عنوان ژورنال:
  • Science translational medicine

دوره 8 370  شماره 

صفحات  -

تاریخ انتشار 2016